Substituted 6-azaandrostenones

Details Substituted 6-azaandrostenones Substituted 6-azaandrostenones

C - Chemistry, Metallurgy

07

J

C07J 73/00 (2006.01) A61K 31/58 (2006.01) C07C 211/40 (2006.01) C07C 211/41 (2006.01) C07C 211/45 (2006.01) C07C 211/52 (2006.01) C07D 309/14 (2006.01) C07D 317/58 (2006.01) C07D 335/02 (2006.01)

Patent

CA 2152053

The present invention relates to certain substituted 17.beta.-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I). wherein R1 and R2 i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R1 and R2 is a single or a double bond, or ii) taken together are a -CH2- group forming a cyclopropane ring, and the bond between the carbons bearing R1 and R2 is a single bond; R3 is preferably hydrogen, halogen or lower alkyl, R4 is preferably hydrogen or lower alkyl, X is preferably CH2, Y is preferably hydrogen and Z is preferably CONR14R15 and R14 and R15 are a variety of organic groups, and pharmaceutically acceptable salts thereof, preparation, medical use and pharmaceutical formulations.

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