Substituted acetamide derivatives

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 323/41 (2006.01) A61K 31/165 (2006.01) A61K 31/33 (2006.01) C07C 317/32 (2006.01) C07C 317/44 (2006.01) C07C 323/60 (2006.01) C07D 213/70 (2006.01) C07D 215/36 (2006.01) C07D 233/28 (2006.01) C07D 233/84 (2006.01) C07D 239/38 (2006.01) C07D 263/46 (2006.01) C07D 277/36 (2006.01) C07D 307/91 (2006.01) C07D 333/18 (2006.01) C07D 333/62 (2006.01)

Patent

CA 2105617

ABSTRACT OF THE DISCLOSURE There are provided substituted acetamide derivatives represented by general formula (I): Image (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, n and Z are defined in the specification. The substituted acetamide derivatives strongly inhibit acyl- coenzyme A cholesterol acyltransferase (ACTA) and are expected to be effective for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.

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