Substituted acetophenones and process therefor

Details Substituted acetophenones and process therefor Substituted acetophenones and process therefor

C - Chemistry, Metallurgy

07

C

260/386, 260/489

C07C 49/82 (2006.01) C07C 45/74 (2006.01) C07C 49/84 (2006.01) C07C 69/02 (2006.01) C07D 207/333 (2006.01) C07D 213/50 (2006.01) C07D 213/80 (2006.01) C07D 241/24 (2006.01) C07D 307/40 (2006.01) C07D 307/46 (2006.01) C07D 317/54 (2006.01) C07D 333/22 (2006.01)

Patent

CA 1124254

ABSTRACT Process for the preparation of antivirally active compounds of the formula Image II wherein R1' represents hydroxy, acyloxy derived from an aliphatic acid having 2-18 carbon atoms or a heterocyclic carboxylic acid containing mitrogen atom(s), lower alkoxycarbonyloxy, aminoacyloxy or carboxyalkanoyloxy; R2' represents lower alkoxy; R3' represents lower alkoxy; and R4' represents phenyl which is substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, benzyloxy, allyloxy, alkylthio, dealkylamino, amino and cyano; lower slkyl-substi- tuted furyl or pyridyl, thienyl or pyrrolyl which may be substituted by lower alkyl, with the provise that when R4' is p-methoxyphenyl, R1' is a radical other than acetoxy, which process comprises a) reacting a compound of the formula Image III wherein R2' and R3' are as defined above, with an aldehyde or formula R4'-CH0 IV wherein R4' is as defined above, in an organic solvent in the presence of a basic cata- lyst, or b) reacting a compound of formula Image V wherein R2', R3' and R4' are as defined above, and M represents a hydrogen atom or an alkali metal, with an acid anhydride or an acid halide derived from an aliphatic mono- or dicarboxylic acid having 2-18 car- bon atoms, a heterocyclic carboxylic acid containing ni- trogen atom(s) or an amino acid in an organic solvent and pharmaceutical compositions containing them.

343964

Affiliated with

Also associated with

Rating

Substituted acetophenones and process therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted acetophenones and process therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted acetophenones and process therefor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-328972