C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/52 (2006.01) A61K 31/166 (2006.01) A61P 3/14 (2006.01) A61P 19/08 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2608180
The invention provides a pharmaceutical composition having excellent anti- osteoporosis activity, anti-inflammation activity, anti-rheumatoid arthritis activity and anti-hypercalcemia activity. Preferred are compositions comprising a compound of Formula (I') or a pharmacologically acceptable salt thereof as an active ingredient: (see formula I') wherein: R5 and R6 each independently represent a substituent on a benzene ring, the substituent being selected from substituent group a; R7 represents a hydrogen atom, a C1-C6 haloalkyl group, a C1-C6 hydroxyalkyl group which may be protected by a hydroxyl protecting group, a C1- C6 alkyl group which may be substituted with one group or more than one group selected from substituent group .beta., a C6-C10 aryl group which may be substituted with one group or more than one group selected from substituent group a, or a C3- C10 cycloalkyl group which may be substituted with one group or more than one group selected from substituent group .alpha.; m represents an integer of 1 to 3; n represents an integer of 1 to 3; and the numerals on each benzene ring represent the position number of each substitution.
La présente invention concerne une composition pharmaceutique comprenant un composé présentant la formule générale (I) ou un sel pharmacologiquement acceptable de ce composé utilisé en tant que principe actif : (I) dans laquelle R1 représente un groupe aryle en C6 à C10 pouvant être substitué par un résidu sélectionné dans le groupe substituant .alpha. ou analogue, R2 représente un groupe aryle en C6 à C10 pouvant être substitué par un résidu sélectionné dans le groupe substituant .alpha. ou analogue ; et X représente un groupe hydroxyle, un groupe alcoxy en C1 à C6 ou analogue.
Aoki Kazumasa
Kaneko Toshio
Kimura Tomio
Suda Koji
Daiichi Sankyo Company Limited
Marks & Clerk
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