Substituted acyl dertivatives of...

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C - Chemistry, Metallurgy

07

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167/226, 260/284

C07D 215/16 (2006.01) A61K 31/47 (2006.01) A61P 9/12 (2006.01) C07D 217/26 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341330

Substituted acyl derivatives of 1,2,3,4-tetra- hydroisoquinoline-3-carboxylic acids and the pharma- ceutically acceptable salts thereof are produced by coupling a suitably substituted 1,2,3,4-tetrahydro- isoquinoline with a suitably substituted amino acid and when desired hydrolysing or removing protecting groups of the resulting product. The compounds of the invention, their salts and.pharmaceutical compositions thereof are useful as antihypertensive agents.

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