(substituted)acyl dipeptidyl inhibitors of the ice/ced-3...

Details (substituted)acyl dipeptidyl inhibitors of the ice/ced-3... (substituted)acyl dipeptidyl inhibitors of the ice/ced-3...

C - Chemistry, Metallurgy

07

C

C07C 237/22 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) C07C 311/09 (2006.01) C07D 209/42 (2006.01) C07D 211/60 (2006.01) C07D 211/86 (2006.01) C07D 213/64 (2006.01) C07D 215/227 (2006.01) C07D 215/233 (2006.01) C07D 215/24 (2006.01) C07D 217/24 (2006.01) C07D 217/26 (2006.01) C07D 231/06 (2006.01) C07D 233/84 (2006.01) C07D 235/26 (2006.01) C07D 235/28 (2006.01) C07D 237/14 (2006.01) C07D 239/34 (2006.01) C07D 239/38 (2006.01) C07D 239/88 (2006.01) C07D 249/12 (2006.01) C07D 257/04 (2006.01) C07D

Patent

CA 2347792

This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

L'invention concerne des nouveaux composés inhibiteurs acyle(substitué) dipeptidyle de la famille ICE/ced-3. Elle concerne également des compositions pharmaceutiques contenant ces composés, de même que l'utilisation de telles compositions dans le traitement de patients souffrant de maladies inflammatoires, auto-immunes et neurodégénératives, dans la prévention de lésions ischémiques et dans la conservation d'organes destinés à une procédure de transplantation.

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