(substituted)acyl dipeptidyl inhibitors of the ice/ced-3...

Details (substituted)acyl dipeptidyl inhibitors of the ice/ced-3... (substituted)acyl dipeptidyl inhibitors of the ice/ced-3...

C - Chemistry, Metallurgy

07

K

C07K 5/023 (2006.01) A61K 38/05 (2006.01) A61P 9/10 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) C07C 237/22 (2006.01) C07K 5/027 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2475653

This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

L'invention concerne des composés à base d'inhibiteurs de dipeptidyle d'acide substitué de la famille ICE/ced-3 des protéases de cystéine. Elle concerne aussi des compositions pharmaceutiques contenant ces composés ainsi que leur utilisation pour le traitement des patients souffrant de maladies inflammatoires, auto-immunes et neurodégénératives, à des fins de prévention d'accidents ischémiques et de conservation d'organes à transplanter.

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