Substituted acylhydroxamic acids and method of reducing...

Details Substituted acylhydroxamic acids and method of reducing... Substituted acylhydroxamic acids and method of reducing...

C - Chemistry, Metallurgy

07

D

C07D 209/48 (2006.01) A61K 31/4035 (2006.01) A61K 31/4439 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07D 209/46 (2006.01) C07D 209/64 (2006.01) C07D 209/66 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2394604

Imido and amido substituted acylhydroxamic acids which reduce the levels of TNF.alpha. and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4- methoxyphenyl)propanoylamino)propanoate.

L'invention concerne des acides acylhydroxamiques imido et amido substitués qui réduisent les taux de TNF.alpha. et qui inhibent la phosphodiestérase chez un mammifère. Un mode de réalisation typique est représenté par le (3-(1,3-dioxoisoindoline-2-yl)-3-(3-éthoxy-4-méthoxyphényl)propanoylamino)propanoate.

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