Substituted alkyl-pyridazinones for the treatment of memory...

A - Human Necessities – 61 – K

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A61K 31/501 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2504959

The compounds of the general Formula I, wherein R1 stands for hydrogen or lower alkyl; one of symbols X and Y stands for hydrogen or halogen and the other represents a group of the general Formula II, R2 is hydrogen or lower alkyl; n is 1, 2 or 3; R3 is hydrogen, lower alkyl or aryl-lower alkyl; Z is - 0-; or R3 and Z together with the intermediate atoms form a piperazino ring; Q and W independently from each other stands for -CH= or -N=; and R4, R5 and R6 can be the same or different and stand for hydrogen, halogen, trifluoromethyl or lower alkoxy; or R4 and R5 together form an ethylenedioxy group) and pharmaceutically acceptable salts thereof can be used for the treatment or prophylaxis of malfunctions of memory and/or cognitive decline or prevention of decline of learning abilities.

La présente invention a trait à des composés de formule générale (I), dans laquelle : R?1¿ représente l'hydrogène ou un alkyle inférieur, un parmi les symboles X et Y représente hydrogène ou halogène et l'autre représente un groupe de formule générale II ; R?2¿ est hydrogène ou alkyle inférieur ; n est 1, 2 ou 3 ; R?3¿ est hydrogène, alkyle inférieur ou aryle-alkyle inférieur ; Z est -O- ; ou R?3¿ et Z ensemble avec les atomes intermédiaires forment un cycle pipérazino ; Q et W, indépendamment l'un de l'autre, représente -CH= ou -N= ; et R?4¿, R?5¿ et R?6¿, identiques ou différents, représentent hydrogène, halogène, trifluorométhyle ou alkoxy inférieur, ou R?4¿ et R?5¿ ensemble forment un groupe ethylènedioxy ; et des sels pharmaceutiquement acceptables desdits composés pouvant être utilisés pour le traitement ou la prévention de dysfonctionnements de la mémoire et/ou le déficit cognitif ou la prévention du déclin d'aptitude à l'apprentissage.

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