Substituted alkylamide derivatives of teicoplanin

Details Substituted alkylamide derivatives of teicoplanin Substituted alkylamide derivatives of teicoplanin

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 38/14 (2006.01)

Patent

CA 2046880

The present invention is directed to new C63 amide derivatives of teicoplanin wherein the amide moiety is derived from a di- or poly-alkylamine, and to a process for preparing them. The derivatives are prepared by reacting a teicoplanin-like product with an active ester forming reagent such as chloroacetonitrile and then contacting said active ester with the approp- riate di- or poly-alkylamine. The amide derivatives of the invention are active against gram positive and gram negative bac- teria.

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