Substituted alkylamine derivatives

Details Substituted alkylamine derivatives Substituted alkylamine derivatives

C - Chemistry, Metallurgy

07

C

167/179, 260/242

C07C 217/58 (2006.01) C07C 211/27 (2006.01) C07C 211/30 (2006.01) C07C 211/46 (2006.01) C07C 211/49 (2006.01) C07C 217/48 (2006.01) C07C 233/20 (2006.01) C07C 237/40 (2006.01) C07C 255/54 (2006.01) C07C 323/32 (2006.01) C07D 213/30 (2006.01) C07D 213/36 (2006.01) C07D 213/38 (2006.01) C07D 213/64 (2006.01) C07D 215/14 (2006.01) C07D 231/12 (2006.01) C07D 261/08 (2006.01) C07D 263/32 (2006.01) C07D 277/24 (2006.01) C07D 277/28 (2006.01) C07D 307/42 (2006.01) C07D 307/52 (2006.01) C07D 307/68 (2006.01) C07D 3

Patent

CA 1319689

Abstract of the Disclosure A substituted alkylamine derivative represented by the general formula (I) Image wherein A represents a methine group, a nitrogen atom, an oxygen atom or a sulfur atom; Q re- presents a group which may contain one or two hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms and forms a 5- or 6-membered aromatic ring together with the adjacent carbon atoms and A (the aromatic ring may contain one substituent, or two iden- tical or different substituents, selected from the class consisting of halogen atoms, hydroxyl groups, lower alkyl groups and lower alkoxy groups); X and Y may be identical or different and each represents an oxygen atom, a sulfur atom, a carbonyl group, a group of the formula -CHRa- in which Ra represents a hydrogen atom or a lower alkyl group, or a group of the formula -NRb- in which Rb represents a hydrogen atom or a lower alkyl group, or when taken together, X and Y represent a vinylene or ethynylene group; R1 represents a lower alkenyl group which may be substituted, a cycloalkenyl group which may be substituted, a lower alkynyl group which may be substituted, an aryl group which may be substituted, or a heterocyclic group which may be substituted;R2 represents a hydrogen atom or a lower alkyl group; R3 re- presents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a cycloalkyl group; R4 and R5 may be identical or different and each represents a hydrogen atom or a halogen atom; and R6 represents an acyclic hydrocarbon group which may be substi- tuted (which may contain 1 or 2 unsaturated bonds selected from double and triple bonds); a cycloalkyl group which may be substituted, or a phenyl group which may be substituted; provided that when either one of X and Y re- presents an oxygen or sulfur atom, or the group -NRb- in which Rb is as defined above, the other represents a carbonyl group or the group -CHRa- in which Ra is an defined above, and a nontoxic salt thereof. The said compound is useful as pharmaceuticals, particularly for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.

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