Substituted alkylaminopyridazinone derivatives, process for...

C - Chemistry – Metallurgy – 07 – D

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C07D 237/22 (2006.01) A61K 31/50 (2006.01) A61P 25/22 (2006.01) A61P 25/28 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2461467

New substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; X is hydrogen or halogen; R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; Q and W independently from each other stand for -N= or -CH=; and R4 and R5 independently from each other represent hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof possess useful anxiolytic and cognition enhancing properties.

L'invention porte sur de nouveaux dérivés d'alkylaminopyridazinone substitués représentés par la formule générale (I) (dans laquelle R¿1? représente un hydrogène ou un alkyle possédant de 1 à 4 atomes de carbone; X représente un hydrogène ou un halogène; R¿2? représente un hydrogène ou un alkyle possédant de 1 à 4 atomes de carbone; n vaut 1, 2 ou 3; Q et W, indépendamment l'un de l'autre, représentent -N= ou -CH=; et R¿4? et R¿5?, indépendamment l'un de l'autre, représentent un hydrogène, un halogène, un trifluorométhyle ou un alkoxy possédant de 1 à 4 atomes de carbone). L'invention porte également sur des sels d'addition de ces dérivés acceptables d'un point de vue pharmaceutique. Ces nouveaux dérivés possèdent des propriétés nootropiques et anxiolytiques utiles

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