C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/18 (2006.01) A61K 31/215 (2006.01) A61K 31/27 (2006.01) A61K 31/405 (2006.01) C07C 233/78 (2006.01) C07C 237/20 (2006.01) C07C 237/52 (2006.01) C07C 271/22 (2006.01) C07D 209/20 (2006.01)
Patent
CA 2193348
The present invention relates to novel substituted alkyldiamine derivatives of formula (1), wherein G1 and G2 are -CH2- or -C(O)-; Ar1 and Ar2 represent a radical chosen from the group (II), Ar3 is a radical chosen from the group (III). The compounds are useful tachykinin antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions including asthma, cough, and bronchitis.
La présente invention a pour objet de nouveaux dérivés d'alkyldiamines substituées de formule (1) où G¿1? et G¿2? représentent -CH¿2?- ou C(O)-; Ar¿1? et Ar¿2? représentent un radical sélectionné dans le groupe (II); Ar¿3? représente un radical sélectionné dans le groupe (III). Ces composés constituent d'utiles antagonistes de la tachykinine. Ces antagonistes sont utilisés dans le traitement de maladies provoquées par la tachykinine et des affections telles que l'asthme, la toux et la bronchite.
Burkholder Timothy P.
Kudlacz Elizabeth M.
Le Tieu-Binh
Aventis Inc.
Osler Hoskin & Harcourt Llp
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