C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 271/28 (2006.01) A61K 31/195 (2006.01) C07C 271/12 (2006.01) C07C 271/22 (2006.01)
Patent
CA 2383002
The present invention is directed to novel substituted .alpha.-hydroxy acid thereof, represented by general Formula (I), where R1-R5, X and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
L'invention concerne des nouveaux acides .alpha.-hydroxy substitués, représentés par la formule (I), où R¿1?-R¿5?, X et Z sont définis tels que dans le descriptif. L'invention concerne également une découverte montrant que les composés représentés par la formule (I) sont des inhibiteurs potentiels de caspases et de mort cellulaire par apoptose. En conséquence, ces inhibiteurs peuvent retarder ou bloquer la mort cellulaire dans différentes conditions cliniques, dans lesquelles la perte de cellules, de tissus ou d'organes entiers peut survenir.
Cai Sui Xiong
Green Douglas R.
Guan Lufeng
Mills Gordon B.
Wang Yan
Cytovia Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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