Substituted amide derivatives as protein kinase inhibitors

Details Substituted amide derivatives as protein kinase inhibitors Substituted amide derivatives as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2605680

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

La présente invention concerne des composés sélectionnés qui sont efficaces dans la prophylaxie et le traitement de maladies telles que les maladies induites par le facteur de croissance des hépatocytes (HGF). La présente invention décrit de nouveaux composés, analogues, promédicaments et sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques et des procédés de prophylaxie et de traitement des maladies et d~autres pathologies ou états tels que le cancer et analogues. Cette invention concerne également des procédés de préparation de tels composés ainsi que des intermédiaires utiles dans de tels procédés.

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