Substituted amides, method of making, and use as btk inhibitors

Details Substituted amides, method of making, and use as btk inhibitors Substituted amides, method of making, and use as btk inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/381 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 241/20 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 417/12 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2723237

Compounds of Formula I that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula I, together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients. are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/ or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.

Cette invention concerne des composés de formule I inhibant Btk. Linvention concerne également des compositions pharmaceutiques comprenant au moins un composé de formule I, avec au moins un excipient pharmaceutiquement acceptable choisi parmi des vecteurs, des adjuvants et des excipients. Linvention concerne par ailleurs des méthodes de traitement de patients atteints de certaines maladies sensibles à linhibition de lactivité Btk et/ou de lactivité des lymphocytes B. Linvention concerne aussi la détermination de la présence de Btk dans un échantillon.

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