Substituted amidines having high binding to the sigma...

Details Substituted amidines having high binding to the sigma... Substituted amidines having high binding to the sigma...

C - Chemistry, Metallurgy

07

C

C07C 257/10 (2006.01) A61K 31/155 (2006.01) A61K 31/33 (2006.01) A61K 51/04 (2006.01) C07B 59/00 (2006.01) C07C 257/14 (2006.01) C07D 207/34 (2006.01) C07D 213/78 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2089261

2089261 9204054 PCTABS00011 N,N'-disubstituted-amidines, e.g., of formula (I), wherein R, R' and R" are substituted or unsubstituted hydrocarbon and/or heterocyclic groups. Methods are provided for the treatment or prophylaxis of anxiety in an animal, for treating psychosis, and for treating hypertension by administering an effective amount of an N,N'-disubstituted amidine which, preferably, has a high affinity for the sigma receptor.

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