Substituted amine derivatives and methods of use

Details Substituted amine derivatives and methods of use Substituted amine derivatives and methods of use

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/00 (2006.01) A61K 31/4427 (2006.01) A61K 31/4523 (2006.01) A61K 31/455 (2006.01) A61K 31/47 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07D 231/56 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2434178

Selected amines of formula (I) are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

L'invention concerne des amines sélectionnées, qui sont efficaces pour la prévention et le traitement de pathologies telles que les maladies s'accompagnant d'une angiogenèse. L'invention concerne de nouveaux composés, des analogues, des précurseurs, et des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques et des méthodes de prévention et de traitement de maladies, et d'autres pathologies et troubles associés à une angiogenèse, notamment les cancers et les pathologies voisines. L'invention concerne également des procédés permettant de préparer de tels composés ainsi que des produits intermédiaires utiles dans ces procédés.

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