Substituted amines for the treatment of neurological disorders

Details Substituted amines for the treatment of neurological disorders Substituted amines for the treatment of neurological disorders

C - Chemistry, Metallurgy

07

D

C07D 233/54 (2006.01) C07D 207/26 (2006.01) C07D 207/32 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/14 (2006.01) C07D 211/76 (2006.01) C07D 231/12 (2006.01) C07D 233/22 (2006.01) C07D 235/12 (2006.01) C07D 235/14 (2006.01) C07D 249/04 (2006.01) C07D 249/08 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2461603

Disclosed are compounds of formula (I) which are useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

L'invention concerne des composés de formule (I) qui sont utiles pour le traitement de la maladie d'Alzheimer et d'autres maladies similaires. Lesdits composés comprennent des inhibiteurs d'enzyme bêta sécrétase qui sont utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par le dépôt d'un peptide A bêta dans un mammifère. Lesdits composés de l'invention sont utiles dans des compositions pharmaceutiques et des méthodes de traitement pour réduire la formation de peptide A bêta.

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