Substituted amino acids as neutral sphingomyelinase inhibitors

Details Substituted amino acids as neutral sphingomyelinase inhibitors Substituted amino acids as neutral sphingomyelinase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 229/36 (2006.01) A61K 31/19 (2006.01) A61K 31/435 (2006.01) C07C 229/14 (2006.01) C07C 229/22 (2006.01) C07D 209/20 (2006.01) C07D 215/12 (2006.01) C07D 229/00 (2006.01) C07D 231/38 (2006.01) C07K 5/06 (2006.01) C07K 5/072 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2399792

This invention relates to a series of substituted amino acids of Formula (I), pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules that bind to neutral sphingomyelinase and inhibit its activity.

L'invention concerne une série d'acides aminés substitués représentés par la formule (I), des compositions pharmaceutiques contenant ceux-ci et des produits intermédiaires utilisés dans la fabrication de ceux-ci. Ces composés sont de petites molécules qui se lient à la sphingomyélinase neutre et inhibent l'activité de celle-ci.

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