C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/58 (2006.01) A61K 31/435 (2006.01) A61K 31/4468 (2006.01) A61P 33/06 (2006.01) C07D 207/14 (2006.01) C07D 223/12 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2423315
The invention relates to novel compounds which are substituted amino-aza- cycloalkane derivatives of the general formula I. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of general formula I and especially their use as inhibitors of the plasmodium falciparum protease plasmepsin II or related aspartic proteases.
L'invention concerne des composés qui sont des dérivés amino-aza-cycloalcane substitués de formule générale I. Elle concerne aussi des réalisations s'y rapportant notamment des procédés de préparation de ces composés, des compositions pharmaceutiques contenant un ou plusieurs composé de formule générale I et spécialement leurs utilisations en tant qu'inhibiteurs de plasmepsine II protéase de Plasmodium falciparum ou de protéases aspartiques associées.
Boss Christoph
Fischli Walter
Meyer Solange
Richard-Bildstein Sylvia
Weller Thomas
Actelion Pharmaceuticals Ltd
Gowling Lafleur Henderson Llp
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