Substituted amino carboxylic acids

Details Substituted amino carboxylic acids Substituted amino carboxylic acids

C - Chemistry, Metallurgy

07

D

C07D 307/91 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61P 3/00 (2006.01) C07D 209/08 (2006.01) C07D 215/12 (2006.01) C07D 307/79 (2006.01) C07D 307/80 (2006.01) C07D 317/56 (2006.01) C07D 333/76 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2588776

Disclosed are compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

L'invention concerne des composés et des sels pharmaceutiquement acceptables de la formule (I) lesquels sont utiles dans le traitement de troubles métaboliques associés à la résistance insulinique, la résistance à la leptine ou l'hyperglycémie. Les composés de l'invention comprennent des inhibiteurs de protéine tyrosine phosphatases, en particulier la protéine tyrosine phosphatase-1B (PTP-1B), qui sont utiles dans le traitement du diabète et d'autres maladies médiées par PTP telles que le cancer, les maladies neurodégénératives et analogues. L'invention concerne également des compositions pharmaceutiques contenant les composés de l'invention ainsi que des méthodes de traitement des états précités à l'aide de ces composés.

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