C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/42 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) C07D 215/38 (2006.01) C07D 215/40 (2006.01) C07D 215/42 (2006.01) C07D 215/44 (2006.01) C07D 317/58 (2006.01) C07D 333/20 (2006.01) C07D 333/28 (2006.01)
Patent
CA 2507458
Compounds of formula (I) wherein R is hydrogen, lower alkyl, (C3- C8)cycloalkyl, hydroxy, halo, lower alkoxy, trifluoromethoxy, trifluoromethyl or cyano; and A is biaryl, optionally substituted .beta.-naphthyl, bicyclic heterocyclic aryl, (C3-C6)cycloalkylmonocyclic carbocyclic aryl, or (C5 or C6)cycloalkane fused-monocyclic carbocyclic aryl; pharmaceutically acceptable salts thereof, and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.
La présente invention concerne des composés de formule (I), dans laquelle R représente hydrogène, alkyle inférieur, cycloalkyle (C¿3?-C¿6?), hydroxy, halo, alkoxy inférieur, trifluorométhoxy, trifluorométyhle ou cyano et A représente diaryle, .beta.-naphtyle éventuellement substitué, aryle hétérocyclique bicyclique, aryle carbocyclique monocyclique de cycloalkyle (C¿3?-C¿6?) ou aryle carbocyclique monocyclique fondu de cycloalcane (C¿5? ou C¿6?), des sels de ceux-ci, acceptables d'un point de vue pharmaceutique, ainsi que des esters de ceux-ci, acceptables d'un point de vue pharmaceutique, utilisés dans le traitement de troubles dépendant de COX-2.
Fujimoto Roger Aki
Mcquire Leslie Wighton
Monovich Lauren G.
Mugrage Benjamin Biro
Parker David Thomas
Fetherstonhaugh & Co.
Novartis Ag
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