Substituted aminoethers for the treatment of alzheimer's...

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 233/78 (2006.01) A61K 31/166 (2006.01) A61K 31/277 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/4439 (2006.01) C07C 237/34 (2006.01) C07C 255/57 (2006.01) C07D 213/30 (2006.01) C07D 213/81 (2006.01) C07D 239/26 (2006.01) C07D 263/32 (2006.01) C07D 277/30 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2498269

The invention provides compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

La présente invention a trait à des composés de formule (I), utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies analogues. Lesdits composés comprennent des inhibiteurs de l'enzyme bêta-sécrétase qui sont utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par le dépôt du peptide A bêta chez un mammifère. Les composés de l'invention sont utiles dans des compositions pharmaceutiques et des procédés de traitement pour réduire la formation du peptide A bêta.

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