C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/81 (2006.01) A61K 31/343 (2006.01) A61P 7/02 (2006.01) C07D 307/77 (2006.01) C07D 307/78 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01) C07D 473/04 (2006.01)
Patent
CA 2383257
This invention is directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans of formula (I) that inhibit Factor Xa, pharmaceutical compositions comprising these compounds and their use for inhibiting Factor Xa or treating pathological conditions in a patient that may be ameliorated by administration of such compounds. This invention is also directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans which directly inhibit both Factor Xa and Factor Ha (thrombin), to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds and to a method of simultaneously directly inhibiting both Factor Xa and Factor IIa (thrombin).
L'invention concerne des dihydrobenzofuranes et des benzopyranes (aminoiminométhyle ou aminométhyle) substitués inhibant le facteur Xa, des compositions pharmaceutiques renfermant ces composés et leur utilisation pour inhiber le facteur Xa ou traiter des états pathologiques chez un patient pouvant être améliorés par administration de tels composés. La présente invention porte également sur des dihydrobenzofuranes et des benzopyranes (aminoiminométhyle ou aminométhyle) substitués inhibant directement à la fois le facteur Xa et le facteur Ila (thrombine), des compositions pharmaceutiques renfermant ces composés, des intermédiaires utiles pour préparer ces composés et un procédé inhibant directement et en même temps à la fois le facteur Xa et le facteur Ila (thrombine).
Burns Christopher J.
Dankulich William P.
Mcgarry Daniel G.
Volz Francis A.
Aventis Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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