C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07D 213/85 (2006.01) C07F 5/00 (2006.01)
Patent
CA 2654789
The invention relates to substituted pyrazolopyridines according to the general formula (I) : in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted pyrazolopyridine compounds, to methods of preparing said substituted pyrazolopyridines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.
La présente invention concerne des pyrazolopyridines substituées de formule générale (I) : dans laquelle A, B, D, E, Ra, R1, R2, R3, R4, R5 et q sont tels que définis dans les revendications, ainsi que leurs sels, les compositions pharmaceutiques comprenant lesdites pyrazolopyridines substituées, les méthodes de synthèses desdites pyrazolopyridines substituées et leurs emplois dans la fabrication d'une composition pharmaceutique destinée au traitement de maladies impliquant un dérèglement de la croissance vasculaire ou de maladies accompagnées d'un dérèglement de la croissance vasculaire, les composés interférant de façon active avec la signalisation par Tie2.
Boemer Ulf
Briem Hans
Hartung Ingo
Ince Stuart
Kettschau Georg
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
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