Substituted amylose as a matrix for sustained drug release

Details Substituted amylose as a matrix for sustained drug release Substituted amylose as a matrix for sustained drug release

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/28 (2006.01) C08B 33/04 (2006.01)

Patent

CA 2271895

A pharmaceutical sustained release tablet for oral administration is made of a compressed blend of at least two dry powders including a powder of a pharmaceutical drug and a powder of a sustained release matrix for the drug. The sustained release matrix is made of substituted amylose prepared by reacting, in a basic medium, amylose with an organic substituent having a reactive function that reacts with the hydroxy groups of the amylose molecule. This substituent is preferably an epoxy or halogen alkane or alcohol with such a matrix controlled and sustained release of a drug are achieved with a remarkable close-to-linear profile and a release time of from 9 to 20 hours.

L'invention porte sur un comprimé pharmaceutique s'administrant par voie orale et consistant en un mélange comprimé d'au moins deux poudres sèches dont une poudre d'un médicament et une poudre d'une matrice de libération continue du médicament. Ladite matrice est constituée d'amylose substituée obtenue par réaction en milieu basique d'amylose avec un substituant organique à fonction réactive réagissant avec les groupes hydroxy de la molécule d'amylose. Ce substituant est de préférence un époxy ou un halogénure d'alcane ou un halogénure d'alcool. Avec cette matrice on obtient une libération contrôlée et continue du médicament présentant un profil remarquable quasi linéaire pendant un temps allant de 9 à 20 heures.

Affiliated with

Also associated with

Rating

Substituted amylose as a matrix for sustained drug release does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted amylose as a matrix for sustained drug release, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted amylose as a matrix for sustained drug release will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1402325