C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/22 (2006.01) A61K 31/137 (2006.01) A61K 31/436 (2006.01) A61K 31/4458 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) C07C 215/28 (2006.01) C07C 215/30 (2006.01) C07C 217/34 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2325689
This invention relates to compounds of general formula (Y) wherein A is an aromatic hydrocarbon ring system and R1 is a carbon bound directly to an oxygen and is also bound to a nitrogen through a saturated carbon and wherein at least one of R2, R3 and R4 is an electron-rich substituent. The active agents are useful for treating patients suffering from infections including gram positive organisms, such as streptococcus, staphylococcus, anthracis, gram negative bacteria such as neisseria species, yeasts and mycobacterium. They are effective against strains which have shown resistance to other antimicrobial agents.
L'invention concerne des composés de formule générale (Y) dans laquelle A représente un hydrocarbure aromatique cyclique et R¿1? représente un carbone directement lié à un oxygène, et également lié à un azote par l'intermédiaire d'un carbone saturé, l'un au moins parmi R¿2?, R¿3? et R¿4? représentant un substituant riche en électrons. Ces agents actifs sont utiles pour traiter des patients souffrant d'infections à organismes gram-positifs, tels que le streptocoque, le staphylocoque, l'anthracis, des bactéries gram-négatives comme celle de l'espèce Neisseria, des levures et des mycobactéries. Ces agents sont efficaces contre les souches dont on connaît la résistance à d'autres agents antimicrobiens.
Department Of The Army U.s. Government
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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