Substituted aryl 1,4-pyrazine derivatives

Details Substituted aryl 1,4-pyrazine derivatives Substituted aryl 1,4-pyrazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/497 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2601600

The invention is directed to compounds of Formula (I): (see formula I) and pharmaceutically acceptable salts thereof, wherein R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C(O)C1-C6 alkyl, C(O)C2-C6 alkenyl or C(O)C2-C6 alkynyl; R2 is C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl; R22 is C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl; R3 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, OC1-C6 alkyl, OC2-C6 alkenyl, or OC2-C6 alkynyl; R4 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, OC1-C6 alkyl, OC2-C6 alkenyl, OC2-C6 alkynyl or NR5R6; R5 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl; and R6 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, which act as CRF1 antagonists and are useful in the treatment of disorders and diseases associated with CRF1 receptors, including CNS-related disorders and diseases.

L'invention concerne les composés décrits, représentés par la formule (I), ainsi que les sels pharmaceutiquement acceptables de ces composés, qui agissent comme antagonistes du facteur CRF1, et peuvent être utilisés pour le traitement des troubles et des maladies associés aux récepteurs de CRF1, notamment les troubles et les maladies du SNC.

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