Substituted-aryl 7-aza¬2.2.1|bicycloheptanes for the...

Details Substituted-aryl 7-aza¬2.2.1|bicycloheptanes for the... Substituted-aryl 7-aza¬2.2.1|bicycloheptanes for the...

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/40 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2455773

The invention provides compounds of Formula (I): Formula I wherein the stereochemistry of the of the 7-azabicyclo[2.2.1]heptane ring is 1S, 2R, 4R and the nitrogen substituent at the C-2 carbon has the exo orientation; W is Q, -C=C-Q, or C.ident.C-Q; and Q is as defined herein. These compounds may be in the form of pharmaceutical salts or compositions, and are useful in pharmaceuticals used to treat diseases or conditions in which .alpha.7 is known to be involved.

L'invention porte sur des composés de la formule (I) dans laquelle stéréochimie du cycle 7-azabicyclo[2.2.1]heptane est 1S, 2R, 4R et le substituant azote au niveau du carbone C-2 présente une orientation exo; W représente Q, -C=C-Q ou C.ident.C-Q; et Q est tel que défini dans la demande. Ces composés peuvent se présenter sous la forme de sels ou de compositions pharmaceutiques, et sont utiles dans les produits pharmaceutiques utilisés pour traiter des maladies ou états dans lesquels l'implication de .alpha.7 est connue.

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