C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 257/18 (2006.01) A61K 31/155 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61P 7/02 (2006.01) C07D 207/08 (2006.01) C07D 213/50 (2006.01) C07D 231/12 (2006.01) C07D 233/54 (2006.01) C07D 235/14 (2006.01) C07D 277/24 (2006.01) C07D 333/22 (2006.01)
Patent
CA 2353151
The invention relates to new substituted aryl and heteroaryl derivatives of the general formula (I) Ar - A - HCR1 - X - Y, in which A, Ar, X, Y and R1 have the meanings given in claim 1, and to their tautomers, stereoisomers, mixtures and salts, notably physiologically compatible salts with inorganic or organic acids or bases, which present valuable properties. Accordingly, the compounds of the above general formula (I), in which Y does not contain a cyano group, notably have an antithrombotic action, and the compounds of the above general formula (I), in which Y does not contain a cyano group, are valuable intermediate products for the production of compounds of the general formula (I) in which R5 is a possibly substituted aminomethyl, amidino or guanidino group.
L'invention concerne de nouveaux dérivés aryle et hétéroaryle substitués de la formule générale Ar - A - HCR¿1? - X - Y, dans laquelle A, Ar, X, Y et R¿1? sont définis comme dans la revendication 1, leurs tautomères, leurs stéréoisomères, leurs mélanges et leurs sels, notamment leurs sels physiologiquement tolérables contenant des acides ou des bases inorganiques ou organiques, lesquels dérivés présentent des propriétés précieuses. Ainsi, les composés de la formule générale (I) précitée, dans lesquels Y ne contient aucun groupe cyano, constituent des produits intermédiaires précieux pour la production des composés de la formule générale (I) dans laquelle R¿5? représente un groupe aminométhyle, amidino ou guanidino éventuellement substitué.
Hauel Norbert
Kauffmann Iris
Nar Herbert
Priepke Henning
Ries Uwe
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Boehringer Ingelheim Pharma Kg
Fetherstonhaugh & Co.
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