Substituted aryl hydroxamic acids as metalloproteinase...

Details Substituted aryl hydroxamic acids as metalloproteinase... Substituted aryl hydroxamic acids as metalloproteinase...

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/35 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2330095

The present application describes novel substituted aryl hydroxamic acids of formula (I) or pharmaceutically acceptable salt forms thereof, wherein ring A is a 5-8 membered ring containing from 0-2 heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.

L'invention concerne de nouveaux acides hydroxamiques à substitution aryle représentés par la formule (I): ou leurs sels acceptables sur le plan pharmaceutique, dans laquelle le noyau A est un noyau à 5-8 éléments contenant 0-2 hétéroatomes sélectionnés dans N, O et S, utiles en tant qu'inhibiteurs de métalloprotéinase.

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