C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 27/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 213/85 (2006.01)
Patent
CA 2654105
The invention relates to substituted arylpyrazolopyridines according to the general formula (I) : in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted arylpyrazolopyridines, to methods of preparing said substituted arylpyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.
La présente invention concerne des arylpyrazolopyridines substituées de formule générale (I) : où A, B, D, E, Ra, R1, R2, R3, R4, R5 et q sont tels que définis dans les revendications, ainsi que leurs sels, les compositions pharmaceutiques comprenant lesdites arylpyrazolopyridines substituées, les méthodes de synthèses desdites arylpyrazolopyridines substituées et leur emploi dans la fabrication d'une composition pharmaceutique destinée au traitement de maladies impliquant un dérèglement de la croissance vasculaire ou de maladies accompagnées d'un dérèglement de la croissance vasculaire, les composés interférant de façon active avec la signalisation par Tie2.
Briem Hans
Hartung Ingo
Ince Stuart
Kettschau Georg
Lienau Philip
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
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