C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 335/14 (2006.01) A61K 31/17 (2006.01) C07C 335/16 (2006.01)
Patent
CA 2531068
Substituted arylthiourea compounds of Formula I, and the pharmaceutically acceptable salts of such compounds, useful as antiviral agents, are provided herein. Certain substituted arylthioureas disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions containing one or more substituted arylthiourea compounds and one or more pharmaceutically acceptable carriers, excipients, or diluents are provided herein. Such pharmaceutical compositions may contain a substituted arylthiourea as the only active agent or may contain a combination of a substituted arylthiourea derivative and one or more other pharmaceutically active agents. Methods of treating Hepatitis C viral infections in mammals are also provided herein.
L'invention concerne des composés arylthio-urée substitués de formule I, ainsi que des sels pharmaceutiquement acceptables desdits composés, utilisés en tant qu'agents antiviraux. Certains composés arylthio-urée substitués selon l'invention sont des inhibiteurs puissants et/ou sélectifs de la réplication virale, en particulier de la réplication du virus de l'hépatite C. L'invention concerne encore des compositions pharmaceutiques contenant au moins un desdits composés et au moins un véhicule, excipient ou diluant pharmaceutiquement acceptable. Ces compositions pharmaceutiques peuvent contenir un arylthio-urée substitué comme principe actif unique ou elles peuvent comprendre l'association d'un dérivé arylthio-urée et d'au moins un autre agent pharmaceutiquement actif. L'invention concerne également des méthodes de traitement des infections virales de l'hépatite C chez des mammifères.
Chen Dawei
Li Shouming
Liu Cuixian
Ohkanda Junko
Phadke Avinash
Achillion Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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