Substituted azabicycloalkanes, the use thereof,...

Details Substituted azabicycloalkanes, the use thereof,... Substituted azabicycloalkanes, the use thereof,...

C - Chemistry, Metallurgy

07

D

260/317

C07D 209/52 (2006.01) C07C 205/55 (2006.01) C07C 205/56 (2006.01)

Patent

CA 1208649

Substituted azabicycloalkanes, the use thereof, pharmaceutical compositions containing them, and processes for the preparation of these compounds Abstract of the Disclosure l-Phenyl-3-azabicyclo[3.1.O]hexane-2,4-diones of the formula (I), Image wherein R1 is hydrogen, R2 is hydrogen, sulfo or acyl and R3 is hydrogen, or R1 is a saturated or unsaturated aliphatic, cyclo- aliphatic or cycloaliphatic-aliphatic carbon radical of up to and including 18, preferably of up to and including 12, carbon atoms, R2 is hydrogen, lower alkyl, sulfo or acyl and R3 is hydrogen or lower alkyl, and to salts thereof. and salts thereof; have valuable pharmacological properties and are effective aromatase inhibitors. They can therefore be used for the treatment of hormonal diseases, in particular mammary carcinomas.

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