Substituted azetidin-2-ones for treatment of atherosclerosis

Details Substituted azetidin-2-ones for treatment of atherosclerosis Substituted azetidin-2-ones for treatment of atherosclerosis

C - Chemistry, Metallurgy

07

D

C07D 205/09 (2006.01) A61K 31/395 (2006.01) C07D 403/02 (2006.01)

Patent

CA 2208530

Compounds of formula (I) in which R1 and R2, which may be the same or different, is each selected from hydrogen, halogen or C(1-8)alkyl; R3 is aryl or arylC(1-4)alkyl which may be optionally substituted; X is a linker group; Y is an optionally substituted aryl group; and n is 0, 1 or 2; are inhibitors of the enzyme Lp-PLA2 and thereof of use in treating atherosclerosis.

Composés de la formule (I), dans laquelle R?1¿ et R?2¿, qui peuvent être identiques ou différents, sont chacun choisis parmi hydrogène, halogène ou alkyle C¿1-8?; R?3¿ représente aryle ou arylalkyle C¿1-4? qui peut éventuellement être substitué; X représente un groupe de liaison; Y représente un groupe aryle éventuellement substitué; et n vaut 0, 1 ou 2. Ces composés sont des inhibiteurs de l'enzyme phospholipase A¿2? associée à une lipoprotéine (Lp-PLA¿2?), et sont utilisés pour le traitement de l'athérosclérose.

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