C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/4439 (2006.01) C07D 263/34 (2006.01) C07D 263/48 (2006.01) C07D 277/42 (2006.01) C07D 277/56 (2006.01) C07D 417/06 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2423156
The present invention relates to thiazoles, oxazoles, imidazoles and pharmaceutical compositions comprising said compounds antagonizing the corticotropin releasing factor receptor ("CRF receptor") and useful for the treatment of depression, anxiety, affective disorders, feeding disorders, post- traumatic stress disorder, headache, drug addiction, inflammatory disorders, drug or alcohol withdrawal symptoms and other conditions the treatment of which can be affected by the antagonism of the CRF-1 receptor.
L'invention concerne des thiazoles, des oxazoles, des imidazoles et des compositions pharmaceutiques renfermant lesdits composés ayant une activité antagoniste sur le récepteur du facteur de libération de la corticotropine (récepteur CRF) et étant utiles pour le traitement de dépression, d'anxiété, de troubles affectifs, de troubles alimentaires, du syndrome de stress post-traumatique, de maux de tête, de toxicomanie, de troubles inflammatoires, du syndrome de sevrage d'alcool et de drogues et d'autres pathologies, le traitement de celles-ci pouvant être mis en oeuvre par l'antagonisme du récepteur CRF-1.
Dubowchik Gene M.
Zuev Dmitry S.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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