C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/54 (2006.01) A61K 31/4164 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2551909
The present invention provides azole derivatives of Formula (I), (see formula I) wherein the various variables are defined herein. The present invention also provides methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and their use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of protein tyrosine phosphatases and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases mediated by PTPase activity. Such diseases include Type I diabetes and Type II diabetes.
La présente invention a trait à des dérivés d'azole de formule (I), leurs procédés de préparation, des compositions pharmaceutiques comportant les composés de formule (I), et leur utilisation dans le traitement de troubles humains ou animaux. Les composés de l'invention peuvent être utiles en tant qu'inhibiteurs des protéine tyrosine phosphatases et peuvent donc être utilisés pour la gestion, le traitement, le contrôle, ou traitement additionnel de maladies provoquées par l'intermédiaire d'activité des protéine tyrosine phosphatases. De telles maladies comprennent le diabète de type I et le diabète de type II.
Andrews Robert C.
Arimilli Murty N.
Mjalli Adnan M.m.
Polisetti Dharma R.
Quada James C. Jr.
Smart & Biggar
Transtech Pharma Inc.
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