Substituted azole derivatives, pharmaceutical composition...

Details Substituted azole derivatives, pharmaceutical composition... Substituted azole derivatives, pharmaceutical composition...

C - Chemistry, Metallurgy

07

D

C07D 249/10 (2006.01) A61K 31/554 (2006.01) A61P 25/28 (2006.01) C07D 277/02 (2006.01)

Patent

CA 2751343

Provided are a substituted azole derivative and pharmaceutically acceptable salts thereof, a pharmaceutical composition including an effective amount of the derivative, and a method for treating Parkinson's disease in a mammal including administering an effective amount of the compound to the mammal. The azole derivative of the following Formula (I) and pharmaceutically useful salts thereof have an efficacy against Parkinson's disease from inhibitory effects of the activity of MAO-B.

L'invention porte sur un dérivé d'azole substitué et sur des sels pharmaceutiquement acceptables de celui-ci, sur une composition pharmaceutique comprenant une quantité efficace du dérivé et sur un procédé pour traiter la maladie de Parkinson chez un mammifère comprenant l'administration d'une quantité efficace du composé au mammifère. Le dérivé d'azole de la formule suivante (I) et des sels pharmaceutiquement utiles de celui-ci ont une efficacité contre la maladie de Parkinson à partir d'effets inhibiteurs de l'activité de MAO-B.

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