Substituted benzazoles and use thereof as inhibitors of raf...

Details Substituted benzazoles and use thereof as inhibitors of raf... Substituted benzazoles and use thereof as inhibitors of raf...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/395 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/08 (2006.01)

Patent

CA 2539748

New substituted benz-azole compounds of formula (I), compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

L'invention concerne de nouveaux composés de benzazole substitués de formule (I), des compositions et des méthodes d'inhibition de l'activité de la kinase Raf chez un sujet humain ou animal. Les nouvelles compositions de composés peuvent être utilisées seules ou en combinaison avec au moins un agent supplémentaire pour le traitement d'un trouble médié par la kinase Raf, tel que le cancer.

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