Substituted benzazoles and use thereof as inhibitors of raf...

Details Substituted benzazoles and use thereof as inhibitors of raf... Substituted benzazoles and use thereof as inhibitors of raf...

A - Human Necessities

61

K

A61K 31/4184 (2006.01) A61K 31/428 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2542653

New substituted benzazole compounds of formula (I), compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

L'invention concerne de nouveaux composés de benzazole substitués ayant la formule (I), des compositions et des procédés d'inhibition de l'activité de la Raf kinase chez un sujet humain ou animal. Les nouvelles compositions de composés peuvent s'utiliser isolément ou en combinaison avec au moins un agent d'addition à des fins de traitement d'un trouble à médiation par Raf kinase tel que le cancer.

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