Substituted benzenesulfonylureas and -thioureas, preparation...

Details Substituted benzenesulfonylureas and -thioureas, preparation... Substituted benzenesulfonylureas and -thioureas, preparation...

C - Chemistry, Metallurgy

07

D

C07D 217/24 (2006.01) A61K 31/40 (2006.01) A61K 31/47 (2006.01) A61K 31/5375 (2006.01) C07D 207/38 (2006.01) C07D 209/46 (2006.01) C07D 211/86 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2138930

Substituted benzenesulfonylureas and -thioureas as Antiarrhythmics Benzenesulfonylureas and -thioureas of the formula I Image where R(1) is H or (cyclo)(CH2)a(fluoro)alk(en)yl, R(2) is H, Hal, (fluoro)(mercapto)(CH2)e(cyclo)alk(oxy)(yl) or NR(4)R(5), where R (4) and R (5) together are a (CH2) 2-7 chain, or R (4) , R (5) and R (6) are H or (alkyl)(cyclo)(fluoro)alk(en)yl, E is O or S; Y is -[CR(7)2]n- R(3) is Image B is (C3-C6)-alkenyl, or R(3) is Image X is H, Hal or alkyls; Z is Hal or (cyclo)-alk(yl)oxy. Compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.

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