Substituted benzhydrylamines as handles for solid phase...

Details Substituted benzhydrylamines as handles for solid phase... Substituted benzhydrylamines as handles for solid phase...

C - Chemistry, Metallurgy

07

K

C07K 1/04 (2006.01) C07C 317/32 (2006.01)

Patent

CA 2109433

The present invention is directed to a novel "handle" for solid phase peptide synthesis. The handles can be converted from a stable form to a labile form, allowing for cleavage of a peptide amide from the support after synthesis under mild conditions, and after deprotection of the amino acid side chains. The handles are based on a substituted benzhydrylamine skeleton.

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