Substituted benzimidazole compounds

Details Substituted benzimidazole compounds Substituted benzimidazole compounds

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) C07D 235/30 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2494942

Disclosed are substituted benzimidazole compounds of formula (I) wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and the pharmaceutical compositions comprising these compounds.

L'invention concerne des composés benzimidazole substitués de formule (I) dans laquelle R¿1?, R¿2?, R¿3?, R¿4? et X¿a? sont tels que définis dans la description. Ces composés inhibent la kinase Itk et peuvent de ce fait servir à traiter des maladies ainsi que des états pathologiques, parmi lesquel(le)s figurent l'inflammation, des troubles immunologiques et des troubles allergiques. La présente invention se rapporte en outre à des procédés de préparation de ces composés ainsi qu'à des compositions pharmaceutiques contenant ces composés.

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