Substituted benzimidazole compounds with dual nos inhibitory...

Details Substituted benzimidazole compounds with dual nos inhibitory... Substituted benzimidazole compounds with dual nos inhibitory...

C - Chemistry, Metallurgy

07

D

C07D 409/12 (2006.01) A61K 31/4184 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61K 45/06 (2006.01) C07D 235/12 (2006.01)

Patent

CA 2607219

The present invention relates to benzimidazole compounds having dual nitric oxide synthase (NOS) inhibitory activity and agonist activity at the mu- opioid receptor, to pharmaceutical and diagnostic compositions containing them, and to their medical use, particularly as compounds for the treatment or prevention of chronic pain, acute pain, migraine, and neuropathic pain.

La présente invention porte sur des composés de benzimidazole présentant à la fois une action inhibitrice de la synthase d'oxyde nitrique (NOS) et une action agoniste au niveau du récepteur opioïde mu, sur des compositions pharmaceutiques et diagnostiques les contenant et sur leur utilisation médicale, en particulier comme composés pour le traitement ou la prévention de la douleur chronique, de la douleur aiguë, de la migraine et de la douleur neuropathique.

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