Substituted benzimidazoles and their use for inducing apoptosis

Details Substituted benzimidazoles and their use for inducing apoptosis Substituted benzimidazoles and their use for inducing apoptosis

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/4184 (2006.01) A61K 31/4196 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2553704

The invention relates to compounds of formula (I), wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

L'invention concerne des composés de formule (I) dans laquelle : R représente aryle ou hétéroaryle ; X désigne une liaison, un groupe carbonyle, un dérivé d'un groupe carbonyle, un groupe éthylène ou un groupe éthylènecarbonyle ; R?1¿ représente un amino ou hydroxy éventuellement substitué, et ; les substituants R?2¿ à R?6¿ sont tels que définis dans la description. Cette invention se rapporte en outre à des procédés de synthèse de ces composés, à des compositions pharmaceutiques contenant des composés de formule (I), à des intermédiaires, à l'utilisation d'un composé de formule (I) en tant que médicament ainsi que pour préparer une composition pharmaceutique servant à traiter des maladies néoplasiques et auto-immunes, et à des procédés pour traiter des maladies néoplasiques et auto-immunes au moyen desdits composés de formule (I) ou de compositions pharmaceutiques les contenant.

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