Substituted benzimidazoles as kinase inhibitors

Details Substituted benzimidazoles as kinase inhibitors Substituted benzimidazoles as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/435 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2620472

New substituted benzimidazole compounds of formula (I), compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase or receptor tyrosine kinase mediated disorder, such as cancer.

Cette invention concerne des nouveaux composés benzimidazoles substitués représentés par la formule (I). L'invention concerne également des compositions, et des procédés permettant d'inhiber l'activité des kinases associée à la tumorigénèse chez un sujet humain ou animal. Dans certains modes de réalisation, les composés et les compositions sont efficaces pour inhiber l'activité d'au moins une sérine/thréonine kinase ou un récepteur tyrosine kinase. Les nouveaux composés et les nouvelles compositions de cette invention peuvent être utilisés seuls ou combinés avec au moins un agent supplémentaire pour le traitement d'un trouble induit par une sérine/thréonine kinase ou par un récepteur tyrosine kinase, tel que le cancer.

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