C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/18 (2006.01) A61K 31/415 (2006.01) C07D 235/06 (2006.01) C07D 235/08 (2006.01) C07D 235/12 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2281927
The present invention provides compositions and methods for the treatment of HIV infection. In particular, the present invention provides non-nucleoside inhibitors of reverse transcriptase (RT), as well as methods to treat HIV infection using these non-nucleoside inhibitors of RT. In preferred embodiments, the present invention provides a novel class of substituted benzimidazoles, effective in the inhibition of human immunodeficiency virus (HIV) RT, of the following formula: Image wherein X" is selected from the group consisting of H, methyl, ethyl, cyano, methoxyl, nitro, amine, acetamide, methylamine, dimethylamine, propan-2-ol, isopropenyl, bromine and chlorine; and wherein R" is selected from the group consisting of 2,6-difluorobenzyl, benzyl, ethylbenzyl, 2,6-dichlorobenzyl, 2,3,4,5,6-pentafluorobenzyl, pyridylmethyl, benzenesulfonyl, 2,6-difluorobenzoyl, and 3,3-dimethylallyl.
La présente invention concerne des compositions et méthodes de traitement de l'infection par VIH. En particulier, la présente invention concerne des inhibiteurs non nucléosidiques de transcriptase inverse (RT), ainsi que des méthodes de traitement d'infection par VIH par utilisation de ces inhibiteurs non nucléosidiques de RT. Dans des modes de réalisation préférés, la présente invention décrit une nouvelle classe de benzimidazoles, efficaces dans l'inhibition de la RT du virus de l'immunodéficience humaine (VIH).
Michejda Christopher J.
Morningstar Marshall
Roth Thomas
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Smart & Biggar
LandOfFree
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