Substituted benzimidazoles, process for their preparation...

Details Substituted benzimidazoles, process for their preparation... Substituted benzimidazoles, process for their preparation...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/435 (2006.01) C07D 405/14 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2083714

2083714 9119711 PCTABS00008 The novel compounds of formula (I), wherein R1 and R2, which are different, is each H, alkyl containing 1-4 carbon atoms or -C(O)-R6; one of R1 or R2 is always selected from the group -C(O)-R6; wherein R6 is alkyl containing 1-4 carbon atoms or alkoxy containing 1-4 carbon atoms, R3 is the group -CH2OCOOR7, wherein R7 is alkyl containing 1-6 carbon atoms or benzyl; R4 and R5 are the same or different and selected from -CH3, -C2H5, (a), (b) and -CH2CH2OCH3, or R4 and R5 form together with the adjacent oxygen atoms attached to the pyridine ring and the carbon atoms in the pyridine ring a ring, wherein the part constituted by R4 and R5 is -CH2CH2CH2-, -CH2CH2- or -CH2- as well as pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.

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