Substituted benzo(b)pyrans, processes for their preparation,...

Details Substituted benzo(b)pyrans, processes for their preparation,... Substituted benzo(b)pyrans, processes for their preparation,...

C - Chemistry, Metallurgy

07

D

167/208, 260/300

C07D 405/04 (2006.01) A61K 31/41 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2008247

- 1 - Abstract of the disclosure HOE 89/F 019 Substituted benzo[b]pyrans, processes for their preparation, their use and pharmaceutical preparations based on these compounds Benzo[b]pyran derivatives of the formula I Image I, with E-D equal to CH-CHOH or C = CH; X equal to oxygen or sulfur; Y equal to oxygen, sulfur, So, SO2 or NR9; R1 equal to CN, NO2, Hal, alkoxycarbonyl, SO1-2-alkyl or SO1-2-aryl; R2 equal to H, OH, alkoxy, alkyl, Hal, NR10R11; R3/R4 equal to alkyl; R5/R6 equal to alkyl, (CH2)1-6COO-alkyl, (CH2)1-6CONR10R11, (CH2)0-6COOH,(CH2)1-6CO-alkyl,CO2-alkyl,alkylmercapto- alkyl, alkylsulf(i)(o)nyl, hydroxyalkyl, mercapto- alkyl, aminoalkyl, N-(di)-alkylaminoalkyl or (CH2)fAr with f equal to zero-3; R7/R8 equal to hydrogen, alkyl or phenyl, and m equal to zero-2 are outstanding antihypertensives and spasmolytics. Preparation processes and use are described.

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